Я просто хочу быть спокойным лучшим учеником - Глава 462
Глава 451.
The capsule-shaped drug is researched and sold by Eli Lilly and Company. The Chinese name of the reversed American generic name is Leluoxianfen, and the trade name is Yiweisi.
This drug is usually called Leloxianfen Capsules in China, a box of 12 capsules, the domestic price is 960 RMB, and Ouye will take one capsule every day before pregnancy.
The tablet-like drug is researched and sold by Novartis, Switzerland, and is called Condokran in China.
Speaking of this Swiss pharmaceutical giant, the famous anti-leukemia drug Gleevec produced by them was once very expensive and was called a sky-high price drug.
The Condoklon that Ou Ye eats is not cheap, one bottle of RMB 12 thousand, two bottles a month.
Relying on drugs to hold a sigh of relief, keeping a glimmer of hope for the birth of new medical technology is the greatest motivation for every patient.
However, many patients cannot afford high-priced medicines, and medical insurance can reimburse part of the medicines and cannot afford every medicine in the world.
The most expensive is the most expensive, the root cure is the key.
Shen Qi uses chemical laboratory equipment to conduct professional analysis on Leloxianfen and Condokran. This is a comprehensive operation that requires mastery of organic, inorganic, analytical and other chemical knowledge and practical skills.
Shen Qi found through experiments that Leloxianfen is actually a compound of the benzothiphene class. It is 8oo yuan per pill, and it will be gone if you swallow it. It’s really expensive.
Compared with men, women have stronger immunity, which allows women to resist more infections.
However, due to the role of estrogen and progesterone in the immune response, women are also more susceptible to autoimmune diseases.
The main role of Leloxianfen is to regulate estrogen, which has a good effect on autoimmune diseases in female patients.
The chemical nature of Condokran is a class of oxazolidinone compounds, which is said to be the best anti-Mer’s anemia drug in the world.
From a scientist’s point of view, the so-called sky-high prices are not so mysterious. Their essence is to obtain chemical products through chemical reactions.
“Chemistry, upgrade to level 12.”
“Biology, also promoted me to level 12.”
Зизи!
Тремор!
Shen Qi stunned for a few seconds, then returned to normal, and both chemistry and biology were upgraded to level 12.
Level 11 is the standard master level set by the system, and the chemistry and biology are strong for learning master points, and the highest level can only be hit to the high-level master level of 12.
Level 13 is the top matching master level, and certain conditions must be met before it can be upgraded from the 12 high configuration to the 13 top configuration.
The conditions for upgrading from level 12 to level 13 in chemistry are:
1. 40,000 Xueba points or experience points;
2. Obtain any one of the following chemistry awards to prove the master level of the host.
The system draws up a list, including: Nobel Prize in Chemistry, Wolf Prize in Chemistry, Wiltz Prize in Chemistry, International Carbohydrate Prize, International Catalysis Prize… etc. more than a dozen internationally renowned chemistry awards.
The conditions for upgrading from level 12 to level 13 are:
1. 40,000 Xueba points or experience points;
2. Train at least five outstanding biological doctors.
“…The balance of 3oo12781 Xueba points, please confirm with the host.”
The king of mathematics, physics, chemistry and physiology was born today.
Except for Shen Qi, there should be no one in the world today with 14 grades in mathematics and physics and 12 grades in chemistry and biology.
If chemistry and biology want to continue to upgrade, Shen Qide will achieve academic research results in the real world, or cultivate outstanding young talents.
It is difficult to get the Nobel Prize in Chemistry at Level 12. Shen Qi can fight for other chemistry prizes.
Bringing out 5 excellent Ph.Ds in the biological field takes a lot of time, energy, and emotion, and Shen Qi first needs to be qualified as a doctoral instructor in biology.
Mathematics, physics double 14 grades, chemistry, biology double 12 grades, let’s make do with it first.
Mathematics, physics, chemistry and biology are not completely independent. Mathematics points out the direction, physics ignites sparks, chemistry intersperses left and right, and biology follows closely.
When the level of mathematics, physics and chemistry reaches a certain level, it can be integrated and established, which depends on the perceptive ability of the scientist and the means of integration.
4o1 experiment in the center, Shen Qi’s laboratory alone, he is doing chemistry experiments.
“The Suzuki coupling reaction was used to arylate boronic acid 43.”
“Benzothifene 13 was obtained with a yield of 81%.”
“Recover the ionic liquid (n-methyl, 4-butylimidazole tetrafluoroborate) and use it in the Friedel-Kratz reaction…cough cough!”
During the Friedel-Kratz reaction, a large amount of light red mist was generated in the reaction vessel, which was acidic and pungent.
Even though Shen Qi was wearing a mask, he couldn’t help but cough, and read the chemical literature as he coughed.
According to the literature, Friedel-Kratz responded that it was like this. The experimenter was asked to wear a full set of chemical protection equipment and keep the laboratory ventilated.
The Friedel-Kratz reaction is named after these two chemists, who first demonstrated and reported this reaction.
There are too many person name reactions in organic synthesis. Remembering all the person name reactions and their principles and phenomena is difficult to do.
Shen Qi continued his chemical synthesis experiment.
“The 28c with the complete skeleton of Leloxianfen was obtained with a yield of 79%.”
“Introduction of the 2-hydroxyethylpiperidine side chain through a copper-catalyzed coupling reaction.”
Ionic liquid (n-methyl, 4-butylimidazole tetrafluoroborate) was used again in this step.
Чи-Чи!
The acidic pungent reddish mist diffused for the second time.
Shen Qi is not surprised, and has psychological resistance.
Finally, in the Lewis acidic ionic liquid (trimethylamino aluminum trichloride salt), Shen Qi obtained leroxifene with a yield of 43%.
Leluoxianfen capsules are sold in a box of 96oo yuan, and a capsule of 8oo yuan.
Shen Qi synthesized Leloxianfen in his 4o1 experiment by studying the instructions of Leloxianfen capsules, related chemical literature, and taking the actual Leloxianfen capsules as the sample reference.
In theory, it is like this if Shen Qi’s experimental procedure is correct.
Eli Lilly and Company of the United States will certainly not tell Shen Qi the specific technical details of the preparation of Loxianfen. Shen Qi reversely deduced and obtained Loxianfen.
Whether the Shen Qi version of leroxifene has the same effect as the US version of leroxifene needs further verification.
Even if Shen Qi succeeded in imitating Leloxianfen, he would not be able to sell it because Eli Lilly had already applied for a global patent for this drug.
There should be some chemists in the world with Shen Qi’s reverse engineering ability and operational level.
Gleevec produced by Indians is basically the same as Gleevec in Switzerland. Facts have proved that cheap Indian Gleevec can also save leukemia patients. There must be chemists in India.
“Leloxianfen, are you really effective?” Shen Qi observed his homemade Leloxianfen. His wife took this medicine for many years.
It is very important for Shen Qi to verify the toxicology, pharmacology, pharmacokinetics and drug metabolism properties of the self-made version of leroxianfen.
If Shen Qi successfully synthesizes Ou Ye’s long-term drug in the laboratory, it will give Shen Qi great confidence. Perhaps one day, he can synthesize a new drug with better efficacy.
According to a report by Eli Lilly and Company of the United States, they did pharmacological and toxicological experiments on rats and monkeys during the development stage of leroxifene, which verified the safety of leroxifene and passed the fda (US Food and Drug Administration). ) Certification to obtain the qualification for marketing.
“Monkeys? Where do monkeys go? Monkeys are nationally protected animals.” Shen Qi was lost in thought. It is easy to apply for white mice, but primates for animal experiments are not easy to handle. You have to seek help from the Department of Medicine or the College of Life Sciences. ()
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